期刊
PRENATAL DIAGNOSIS
卷 29, 期 4, 页码 303-311出版社
WILEY
DOI: 10.1002/pd.2206
关键词
neurulation; neural tube defects; embryology; hinge points; spina bifida; anencephaly
资金
- MRC [G0801124, G0601546] Funding Source: UKRI
- Medical Research Council [G0601546, G0801124] Funding Source: researchfish
- Medical Research Council [G0601546, G0801124] Funding Source: Medline
The developmental process of neurulation involves a series of coordinated morphological events, which result in conversion of the flat neural plate into the neural tube, the primordium of the entire central nervous system (CNS). Failure of neurulation results in neural tube defects (NTDs), severe abnormalities of the CNS, which are among the commonest of congenital malformations in humans. In order to gain insight into the embryological basis of NTDs, such as Spina bifida and anencephaly, it is necessary to understand the morphogenetic processes and molecular mechanisms underlying neural tube closure. The mouse is the most extensively studied mammalian experimental model for studies of neurulation, while considerable insight into underlying developmental mechanisms has also arisen from studies in other model systems, particularly birds and amphibians. We describe the process of neural tube formation, discuss the cellular mechanisms involved and highlight recent findings that provide links between molecular signaling pathways and morphogenetic tissue movements. Copyright (C) 2009 John Wiley & Sons, Ltd.
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