期刊
JOURNAL OF FUNCTIONAL FOODS
卷 18, 期 -, 页码 1191-1199出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2015.02.035
关键词
Oregano essential oils; Oxidative stress; Antioxidant; Rats; Intestinal barrier; Tight junctions
资金
- International Scientific and Technological Cooperation Program [2013DFG32510]
- Special Fund for Agro-scientific Research in the Public Interest [201003060]
- Hubei Provincial Creative Team Project of Agricultural Science and Technology [2007-620]
- Hubei Provincial Natural Science Foundation [2013CFA010]
- Fundamental Research Funds for the Central Universities [2013PY047, 2013QC004]
The protective effects of oregano essential oils (OEO) against oxidative stress in intestine of rats were investigated. The results showed that rats orally treated with 5 or 20 mg/kg BW with OEO abolished diquat-induced oxidative stress in jejunum, thereby maintaining jejunal architecture. The protective effect of OEO might cause modification of selected intestinal microbiota, inhibition of inflammatory cytokine expression and subsequent increased occludin expression in jejunum by enhancement of antioxidative capacity. These results revealed that OEO exerted a protective effect against diquat-induced oxidative injury in intestine of rats. (C) 2015 Elsevier Ltd. All rights reserved.
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