期刊
JOURNAL OF FUNCTIONAL FOODS
卷 15, 期 -, 页码 408-417出版社
ELSEVIER
DOI: 10.1016/j.jff.2015.04.001
关键词
Allicin; Cardiovascular disease; Garlic; Gut microbiota; L-carnitine; TMAO
资金
- National Science Council Taiwan [NSC 100-2321-B-002-004, NSC 100-2313-B-002-036, NSC 101-2313-B-002-061-MY2, NSC 102-2628-B-002-010-MY2]
- National Taiwan University, Taiwan [102R-7620]
Trimethylamine N-oxide (TMAO) was recently discovered as a novel and independent risk factor for promoting atherosclerosis while it has been found to be generated from dietary carnitine through metabolism of gut microbiota for decades. Antibiotics were found to successfully inhibit the pathway of gut microbiota-dependent TMAO formation, as well as prevention of atherosclerosis. However, the side effects and resistance potential of antibiotics limit their potential application. Allicin is a well-established antimicrobial phytochemical naturally found in fresh blended garlic and easily acquired from diet. Here we demonstrated that the plasma TMAO levels in C57BL6 mice fed with dietary carnitine were 4-22 times greater than that in the control chow diet group during camitine challenge test. Interestingly, the differences of plasma TMAO level were not seen when comparing mice in camitine plus allicin diet group with the control chow diet group. The results of this study suggest that dietary allicin may be capable of protecting the host from producing TMAO when camitine is consumed through its impact on gut microbiota. Allicin and dietary fresh garlic containing allicin may be used as functional foods for the prevention of atherosclerosis. (C) 2015 Elsevier Ltd. All rights reserved.
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