期刊
JOURNAL OF FUNCTIONAL FOODS
卷 15, 期 -, 页码 52-60出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2015.03.015
关键词
Ganoderma atrum polysaccharide; Cyclophosphamide; Peritoneal macrophages; Spleen lymphocytes; Immunosuppression
资金
- National Key Technology R & D Program of China [2012BAD33B06]
- National Natural Science Foundation of China [31130041]
- Program for New Century Excellent Talents in University [NCET-12-0749]
- State Key Laboratory of Food Science and Technology [SKLF-ZZA-201301]
- Jiangxi Provincial Education Department [KJLD13004]
- Jiangxi Provincial Department of Science and Technology [20141BDH80009]
The molecular mechanism underlying the chemoprotective effects of Ganoderrna atrum polysaccharide in cyclophosphamide-induced immunosuppressed mice was investigated. In Cy-treated mice, PSG-1 treatment significantly promoted the phagocytosis, and stimulated the production of NO and cytokines (TNF-alpha and IL-1 beta) in peritoneal macrophages. Moreover, PSG-1 elevated the phosphorylation of MAPKs and Akt, as well as expression of NP-kappa B in peritoneal macrophages. In addition, PSG-1 enhanced the recovery of T and B cell proliferation responses in Cy-treated mice. Furthermore, Ca2+ concentration and PKC activity of spleen lymphocytes in PSG-1 groups dramatically increased as compared with that of the model group. Finally, PSG-1 administration was found to dose-dependently improve the decline of cAMP level and PICA activity caused by Cy. These findings indicated that the chemoprotective effects of PSG-1 may be attributed to its capacity to activate peritoneal macrophages and spleen lymphocytes in Cy-treated mice. (C) 2015 Elsevier Ltd. All rights reserved.
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