期刊
JOURNAL OF FUNCTIONAL FOODS
卷 19, 期 -, 页码 563-574出版社
ELSEVIER
DOI: 10.1016/j.jff.2015.09.045
关键词
Gancao (Glycyrrhiza inflata Batal); Cancer chemopreventive agents; Flavonoids; NQO1; Molecular docking; Tumour angiogenesis
资金
- National Natural Science Foundation of China [81173531, 81473108, U1403102]
- Shenyang Science and Technology Research Project [F15-199-1-26]
- research project for key laboratory of Liaoning Educational Committee [LZ2015067]
Bioactivity guided assay of Gancao showed the flavonoids as being effective in its extract, which contained 24 flavonoids, including isoflavones (1-4), flavanones (5-7), chalcones (8-17), and flavones (18-24). Components 1, 5, 6, 7, 8, 9, 19, 21, and 22 were for the first time identified in licorice. NQO1 and tumour angiogenesis assay suggested three effective flavonoids, alpha, 4, 2', 4' tetrahydroxydihydrochalcone (8), licochalcone A (12), and licoflavone B (20) as being responsible for the chemopreventive effect. Furthermore, AutoDock 4.2 was employed for molecular docking to clarify the interaction between bioactive flavonoids and NQO1. HPLC analysis was performed to determine the contents of 8, 12 and 20. Therefore the chemical and biological results indicated that flavonoids from the residue of Gancao are promising natural cancer chemopreventive agents. (C) 2015 Elsevier Ltd. All rights reserved.
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