期刊
JOURNAL OF FUNCTIONAL FOODS
卷 13, 期 -, 页码 314-322出版社
ELSEVIER
DOI: 10.1016/j.jff.2015.01.006
关键词
Anti-hyperglycaemic; alpha-Glucosidase; Dimocarpus longan Lour; Polyphenol; Chemical composition
资金
- National Science Foundation of China [81341102, 31401473]
- Program for New Century Excellent Talents in University
- Fundamental Research Funds for Northeastern University, China [N130220001, N120820002]
The chemical composition and anti-hyperglycaemic effects of polyphenol-enriched Longan pericarp extracts (LPE) were investigated in the present study. The phenolic profile of LPE was determined by HPLC-DAD/MS analysis. Nine phenolics were identified, and of these, three major components were quantified by LC-MS/MS. Anti-hyperglycaemic assays demonstrate that LPE (polyphenol content ca. 37.8 g gallic acid equivalents/100 g) inhibit a-glucosidase (IC50 = 11.68 +/- 0.44 mu g/mL) in vitro and decrease blood glucose content in mice (P < 0.05) upon sucrose challenge. In addition, LPE improves mouse glucose tolerance following 5 days of treatment by oral gavage (10 mg/kg body weight), which may be due to the increased gene expression associated with insulin signalling pathway, such as insulin receptor substrate-1, peroxisome proliferator-activated receptor gamma and glucose transporter 4. Overall, our results suggest that LPE could impact carbohydrate metabolism and enhance insulin sensitivity and may serve as a potential anti-hyperglycaemic agent in diabetes care. (C) 2015 Elsevier Ltd. All rights reserved.
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