期刊
JOURNAL OF FUNCTIONAL FOODS
卷 14, 期 -, 页码 456-468出版社
ELSEVIER
DOI: 10.1016/j.jff.2015.02.015
关键词
Intestinal microbiota; MiSeq; Obesity; Rat; Ursolic acid
资金
- Key Project of Chinese National Programs for Fundamental Research and Development (973 program) [2012CB124704, 2013CB127301, 2013CB127306]
- National Natural Science Foundation of China [31330075, 31110103909]
- Chinese Academy of Sciences [2013T2S0014]
The intestinal microbiota has been noted to contribute to obesity. Ursolic acid may have potential in the prevention and treatment of obesity, however, little is known about the underlying mechanism. The aim of the present study was to evaluate the effect of the oral intake of ursolic acid on the intestinal microbiota of rats. The results showed that: (i) ursolic acid decreased the microbial diversity in the proximal intestine while having an opposite effect in the distal intestine; (ii) Fat enhanced the effect of ursolic acid on the microbiota in the proximal intestine while attenuating its effect in the distal intestine; (iii) Ursolic acid inhibited colonization by energy harvest-related microbes; and (iv) Ursolic acid may enhance intestinal health by inhibiting colonization by Proteobacteria. Thus, the intestinal microbiota contributes to the function of ursolic acid as a regulator of the nutritional status. (C) 2015 Elsevier Ltd. All rights reserved.
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