期刊
JOURNAL OF FUNCTIONAL FOODS
卷 12, 期 -, 页码 389-398出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2014.11.027
关键词
High fat diet; Obesity; Lipolysis inducing peptides; APPH; Cardiac apoptosis
资金
- Ministry of Science and Technology of Taiwan [MOST102-2410-H-029-054]
- Tunghai University for Global Research and Education on Environment and Society, Taiwan [GREEnS 004-3]
- Taiwan Ministry of Health and Welfare Clinical Trial and Research Centre of Excellence [MOHW103-TDU-B-212-113002]
High-fat-diet (HFD)-induced obesity is a major contributor to diabetes and cardiovascular disease. In this research 6 week old male hamsters (n = 10) fed with HFD showed significant deterioration in heart function as determined from their cardiac ejection fraction percentage (EF%) and fraction shortening percentage (FS%). The number of apoptosis positive cells and the expression of protein markers of apoptosis drastically increased in the HFD-fed hamsters. However, the effects were significantly reduced following the administration of a lipolysis-stimulating peptide-APPH which was derived from the Alcalase-hydrolysis of potato protein. Fifty days of APPH-treatment was effective in all the concentrations (15, 45 and 75 mg/kg/day) tested. The EF% and FS% measurements in the APPH treatment groups were comparable with that of the control group hamsters. The molecular events associated with the ameliorative effect of APPH were found to be potentially mediated by SIRT1 pathway indicating a restoration from the metabolic disorders induced by HFD. (C) 2014 Published by Elsevier Ltd.
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