期刊
JOURNAL OF FUNCTIONAL FOODS
卷 12, 期 -, 页码 199-207出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2014.11.019
关键词
beta-Sitosterol; Cholesterol; beta-Sitosteryl 3 beta-ethoxy; beta-Sitosteryl 3 beta-methoxy
资金
- Hong Kong GRF grants [CUHK 461112, CUHK462813]
beta-Sitosterol (SI) is hypocholesterolemic. The present study investigated whether the blockage of its hydroxyl group would abolish its cholesterol-lowering activity. The blockage was made by methylating and ethylating the hydroxyl group on C3 position, leading to formation of beta-sitosteryl 3 beta-methoxy (SM) and beta-sitosteryl 3 beta-ethoxy (SE) derivatives. Male hamsters were divided into five groups (n =8 each) and fed the non-cholesterol diet (NCD), high cholesterol diet containing 5 mmol of cholesterol (HCD), or one of the three high cholesterol experimental diets with addition of 5 mmol of SI (HCD + SI), 5 mmol of SM (HCD + SM) and 5 mmol of SE (HCD + SE), respectively, for 8 weeks. Results showed that SI could significantly reduce plasma total cholesterol (TC) by 17% (P < 0.05), while SM and SE had no effect on plasma TC. It was concluded that the hydroxyl group was essential for SI to render its cholesterol-lowering activity and its blockage abolished this ability. (C) 2014 Elsevier Ltd. All rights reserved.
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