期刊
JOURNAL OF FUNCTIONAL FOODS
卷 19, 期 -, 页码 676-687出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2015.10.002
关键词
Pterostilbene; Dietary stilbene; Microglia; Antineuroinflammatory effect; MAPK signalling pathways
资金
- National Natural Science Foundation of China [81102432, 81473330, 81173531, J1103606, J1210029]
- Fundamental Research Funds for the Central Universities of China [N130420004, N130120001]
- Research Project for Key Laboratory of Liaoning Educational Committee [LZ2015067]
- Fund for long-term training of young teachers in Shenyang Pharmaceutical University [ZCJJ2013409]
The present study investigated the anti-neuroinflammatory effect of pterostilbene. The data demonstrated that pterostilbene significantly suppresses lipopolysaccharide (LPS)-induced nitric oxide (NO) production and iNOS mRNA expression in BV-2 microglial cells. Pterostilbene significantly inhibits LPS-induced IL-6 and TNF-alpha production and mRNA expression and the phosphorylation of MAPKs.The effect of pterostilbene on neuroinflammation was further confirmed in vivo using a rat neuroinflammation model. Immunohistochemical study indicated that pterostilbene mitigates LPS-induced microglial activation in rat hippocampal CA1 and dentate gyrus (DG). Pterostilbene significantly inhibits LPS-induced IL-6 and TNF-alpha mRNA expression in rat hippocampus and their amount in rat serum. This study demonstrated that pterostilbene possesses anti-neuroinflammatory property, suggesting its potential as a dietary supplement that benefits neurodegenerative diseases associated with neuroinflammation. (C) 2015 Elsevier Ltd. All rights reserved.
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