期刊
JOURNAL OF FUNCTIONAL FOODS
卷 15, 期 -, 页码 525-532出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2015.03.054
关键词
Dendrobium officinale; Polysaccharide; Immunomodulation
资金
- National Key Technology R & D Program of China [2012BAD33B06]
- International Science & Technology Cooperation Program of China [2013DFA32710]
- Program for New Century Excellent Talents in University [NCET-12-0749]
- Key Project of International Cooperation of Jiangxi Provincial Department of Science and Technology [20141BDH80009]
- Project of Science and Technology of Jiangxi Provincial Education Department [KJLD13004]
As part of a series of studies on the bioactivities and structures of polysaccharides from Dendrobium officinale, this study investigates the immunomodulatory activities of Dendrobium officinale and its two polysaccharide fractions (crude and purified, respectively) in cyclophosphamide induced mice. All three materials protected the body from immunosuppression in a dose-dependent manner. Biological activities related to immunomodulations investigated included stimulating the proliferation of splenocytes, balancing the ratio of spleen lymphocyte subsets and the secretion of serum cytokines, up-regulating the serum IgM, IgG and haemolysin formation, and accelerating the phagocytotic function of peritoneal macrophage. The degree of modulations were higher in purified Dendrobium officinale polysaccharide than crude polysaccharide, indicating that the purified polysaccharide was one of the key bioactive components in Dendrobium officinale, the main structure of which has been identified as O-acetyl-glucomannan (Dendronan) (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据