期刊
ONCOTARGETS AND THERAPY
卷 8, 期 -, 页码 461-470出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S78358
关键词
oral squamous carcinoma; time dependent cell proliferation; gene expression
资金
- Model colaborativ institutional pentru translatarea cercetarii stiintifice biomedicale in practica clinica-TRANSCENT [Institutional collaborative model of biomedical scientific research transposed in clinical practice - TRANSCENT] [159/1.5/s/138776]
Epigallocatechin-3-gallate (EGCG) is the major bioactive component of green tea. Our experimental data indicated that EGCG treatment suppresses cell proliferation of SSC-4 human oral squamous cell carcinoma (OSCC), the effect being dose-and time-dependent. In parallel was observed the activation of apoptosis and autophagy, in response to EGCG exposure in SSC-4 cells. Treatment with EGCG activates the expression of the BAD, BAK, FAS, IGF1R, WNT11, and ZEB1 genes and inhibits CASP8, MYC, and TP53. All of these results suggest that EGCG has an excellent potential to become a therapeutic compound for patients with OSCC, by inducing tumor cell death via apoptosis and autophagy.
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