期刊
POSTGRADUATE MEDICINE
卷 122, 期 1, 页码 144-152出版社
TAYLOR & FRANCIS LTD
DOI: 10.3810/pgm.2010.01.2108
关键词
DPP-4 inhibitors; glucose control; HbA(1c); saxagliptin; type 2 diabetes
资金
- Bristol-Myers Squibb
- AstraZeneca
A large percentage of individuals With type 2 diabetes in the United States are not reaching their glycemic goals. In response to data from large outcomes trials and newer classes of therapeutic agents, various organizations and opinion-forming bodies recently updated their clinical practice recommendations for type 2 diabetes. The recommendations, as set by the American Diabetes Association (ADA)/European Association for the Study of Diabetes(EASD), the American Association of Clinical Endocrinologists/American College of Endocrinology and the Canadian Diabetes Association, are similar in their emphasis oil lifestyle modification and the importance of treating fasting and postprandial glucose. both of which are significant contributors to achieving glycated hemoglobin (HbA(1c)) targets. However, the recommendations differ in focus. depth, and specific treatment approaches. With the exception of the ADA/EASD consensus, dipeptidyl peptidase-4 (DPP-4) inhibitors have been included as alternative first- or second-line therapy due. In pal-l. to their glucose-dependent mechanism of action that complements the actions of other oral antidiabetic drugs (OADs). The DPP-4 inhibitor, saxagliptin, demonstrates significant glycemia-lowering effects as monotherapy and in combination therapy, is weight neutral and well tolerated. and has a low risk of hypoglycemia. The added efficacy of saxagliptin in combination with other OADs in improving glycemic parameters has resulted in a significant proportion of patients achieving all HbA(1c) < 7% versus monotherapy or active comparator. Combination therapy with saxagliptin can thus offer a potential advantage in achieving glycemic goals for the majority of patients with type 2 diabetes Without additional tolerability concerns.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据