4.1 Review

Rational design of protein-protein interaction inhibitors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

Constrained Peptides with Target-Adapted Cross-Links as Inhibitors of a Pathogenic Protein-Protein Interaction**

Adrian Glas et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Article Biochemistry & Molecular Biology

A Novel Peptide to Disrupt the Interaction of BST-2 and Vpu

Zeyun Mi et al.

BIOPOLYMERS (2014)

Article Chemistry, Medicinal

Fragment-Based Lead Discovery and Design

Diane Joseph-McCarthy et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2014)

Article Chemistry, Medicinal

Thienoquinolines as Novel Disruptors of the PKCε/RACK2 Protein-Protein Interaction

Florian Rechfeld et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Review Biochemical Research Methods

Twenty years of protein interaction studies for biological function deciphering

Pierre Legrain et al.

JOURNAL OF PROTEOMICS (2014)

Article Multidisciplinary Sciences

2P2IHUNTER: a tool for filtering orthosteric protein-protein interaction modulators via a dedicated support vector machine

Veronique Hamon et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2014)

Article Biochemistry & Molecular Biology

The MIntAct project-IntAct as a common curation platform for 11 molecular interaction databases

Sandra Orchard et al.

NUCLEIC ACIDS RESEARCH (2014)

Article Biochemistry & Molecular Biology

Stapled Peptides with Improved Potency and Specificity That Activate p53

Christopher J. Brown et al.

ACS CHEMICAL BIOLOGY (2013)

Article Oncology

p28, A first in class peptide inhibitor of cop1 binding to p53

T. Yamada et al.

BRITISH JOURNAL OF CANCER (2013)

Article Chemistry, Medicinal

Design of Libraries Targeting Protein-Protein Interfaces

David Fry et al.

CHEMMEDCHEM (2013)

Article Chemistry, Medicinal

Novel toll-like receptor 4 (TLR4) antagonists identified by structure- and ligand-based virtual screening

Urban Svajger et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Chemistry, Medicinal

CSAR Benchmark Exercise 2011-2012: Evaluation of Results from Docking and Relative Ranking of Blinded Congeneric Series

Kelly L. Damm-Ganamet et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2013)

Article Medicine, Research & Experimental

Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies

Yuan-Feng Lin et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Chemistry, Multidisciplinary

Inhibition of α-helix-mediated protein-protein interactions using designed molecules

Valeria Azzarito et al.

NATURE CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

2P2Idb: a structural database dedicated to orthosteric modulation of protein-protein interactions

Marie Jeanne Basse et al.

NUCLEIC ACIDS RESEARCH (2013)

Article Multidisciplinary Sciences

Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

Yong S. Chang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Review Pharmacology & Pharmacy

Targeting protein-protein interactions as an anticancer strategy

Andrei A. Ivanov et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2013)

Article Mathematical & Computational Biology

TIMBAL v2: update of a database holding small molecules modulating protein-protein interactions

Alicia P. Higueruelo et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2013)

Review Chemistry, Multidisciplinary

Comprehensive Peptidomimetic Libraries Targeting Protein-Protein Interactions

Landon R. Whitby et al.

ACCOUNTS OF CHEMICAL RESEARCH (2012)

Article Chemistry, Multidisciplinary

Immunosuppressive Small Molecule Discovered by Structure-Based Virtual Screening for Inhibitors of Protein-Protein Interactions

Tim Geppert et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Review Chemistry, Multidisciplinary

Small-Molecule Stabilization of Protein-Protein Interactions: An Underestimated Concept in Drug Discovery?

Philipp Thiel et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)

Article Chemistry, Medicinal

Protein-Ligand-Based Pharmacophores: Generation and Utility Assessment in Computational Ligand Profiling

Jamel Meslamani et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Chemistry, Medicinal

How Good Are State-of-the-Art Docking Tools in Predicting Ligand Binding Modes in Protein-Protein Interfaces?

Dennis M. Krueger et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Chemistry, Medicinal

Comparison and Druggability Prediction of Protein-Ligand Binding Sites from Pharmacophore-Annotated Cavity Shapes

Jeremy Desaphy et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Biochemistry & Molecular Biology

Docking and scoring with ICM: the benchmarking results and strategies for improvement

Marco A. C. Neves et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2012)

Article Chemistry, Multidisciplinary

Quantifying the chemical beauty of drugs

G. Richard Bickerton et al.

NATURE CHEMISTRY (2012)

News Item Biotechnology & Applied Microbiology

Protein-protein interaction inhibitors get into the groove

Asher Mullard

NATURE REVIEWS DRUG DISCOVERY (2012)

Article Biochemistry & Molecular Biology

ChEMBL: a large-scale bioactivity database for drug discovery

Anna Gaulton et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Biochemistry & Molecular Biology

PocketQuery: protein-protein interaction inhibitor starting points from protein-protein interaction structure

David Ryan Koes et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Multidisciplinary Sciences

The distribution of ligand-binding pockets around protein-protein interfaces suggests a general mechanism for pocket formation

Mu Gao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2

Simon M. Vogel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Mathematical & Computational Biology

Dr. PIAS 2.0: an update of a database of predicted druggable protein-protein interactions

Nobuyoshi Sugaya et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2012)

Article Biochemical Research Methods

sc-PDB: a database for identifying variations and multiplicity of 'druggable' binding sites in proteins

Jamel Meslamani et al.

BIOINFORMATICS (2011)

Review Biochemistry & Molecular Biology

Chemical and structural lessons from recent successes in protein-protein interaction inhibition (2P2I)

Xavier Morelli et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2011)

Review Pharmacology & Pharmacy

Fragment screening to predict druggability (ligandability) and lead discovery success

Fredrik N. B. Edfeldt et al.

DRUG DISCOVERY TODAY (2011)

Article Biochemistry & Molecular Biology

DrugBank 3.0: a comprehensive resource for 'Omics' research on drugs

Craig Knox et al.

NUCLEIC ACIDS RESEARCH (2011)

Review Chemistry, Medicinal

Three-Dimensional Pharmacophore Methods in Drug Discovery

Andrew R. Leach et al.

JOURNAL OF MEDICINAL CHEMISTRY (2010)

Article Multidisciplinary Sciences

Atomic Analysis of Protein-Protein Interfaces with Known Inhibitors: The 2P2I Database

Raphael Bourgeas et al.

PLOS ONE (2010)

Article Biochemistry & Molecular Biology

Atomic Interactions and Profile of Small Molecules Disrupting Protein-Protein Interfaces: the TIMBAL Database

Alicia P. Higueruelo et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2009)

Article Biochemical Research Methods

An empirical framework for binary interactome mapping

Kavitha Venkatesan et al.

NATURE METHODS (2009)

Article Biochemistry & Molecular Biology

Human Protein Reference Database-2009 update

T. S. Keshava Prasad et al.

NUCLEIC ACIDS RESEARCH (2009)

Review Biochemistry & Molecular Biology

Drug-like inhibitors of protein-protein interactions: A structural examination of effective protein mimicry

D. C. Fry

CURRENT PROTEIN & PEPTIDE SCIENCE (2008)

Article Multidisciplinary Sciences

Estimating the size of the human interactome

Michael P. H. Stumpf et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Multidisciplinary Sciences

Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

James A. Wells et al.

NATURE (2007)

Article Biochemistry & Molecular Biology

Strategies to search and design stabilizers of protein-protein interactions: A feasibility study

Peter Block et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)

Article Biochemistry & Molecular Biology

Surflex-Dock 2.1: Robust performance from ligand energetic modeling, ring flexibility, and knowledge-based search

Ajay N. Jain

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2007)

Article Chemistry, Multidisciplinary

Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide

Federico Bernal et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)

Article Biotechnology & Applied Microbiology

Opinion - How many drug targets are there?

John P. Overington et al.

NATURE REVIEWS DRUG DISCOVERY (2006)

Article Biochemistry & Molecular Biology

APID: Agile Protein Interaction DataAnalyzer

Carlos Prieto et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Biochemical Research Methods

The MIPS mammalian protein-protein interaction database

P Pagel et al.

BIOINFORMATICS (2005)

Article Chemistry, Medicinal

LigandScout: 3-d pharmacophores derived from protein-bound Ligands and their use as virtual screening filters

G Wolber et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2005)

Article Chemistry, Medicinal

ZINC - A free database of commercially available compounds for virtual screening

JJ Irwin et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2005)

Article Biochemistry & Molecular Biology

The Biomolecular Interaction Network Database and related tools 2005 update

C Alfarano et al.

NUCLEIC ACIDS RESEARCH (2005)

Review Biotechnology & Applied Microbiology

Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream

MR Arkin et al.

NATURE REVIEWS DRUG DISCOVERY (2004)

Article Multidisciplinary Sciences

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

LD Walensky et al.

SCIENCE (2004)

Article Biochemistry & Molecular Biology

The Database of Interacting Proteins: 2004 update

L Salwinski et al.

NUCLEIC ACIDS RESEARCH (2004)

Article Multidisciplinary Sciences

Binding of small molecules to an adaptive protein-protein interface

MR Arkin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Chemistry, Multidisciplinary

The Cambridge Structural Database: a quarter of a million crystal structures and rising

FH Allen

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE (2002)

Review Biochemistry & Molecular Biology

Antagonists of protein-protein interactions

AG Cochran

CHEMISTRY & BIOLOGY (2000)

Article Biochemistry & Molecular Biology

The Protein Data Bank

HM Berman et al.

NUCLEIC ACIDS RESEARCH (2000)