期刊
POLYMERS FOR ADVANCED TECHNOLOGIES
卷 22, 期 5, 页码 620-626出版社
WILEY
DOI: 10.1002/pat.1555
关键词
thermogelation; hydrogel; injectable material; poly(amino acid); stimuli-responsive polymer; viscoelasticity
Thermoresponsive sol-gel transition polymers based on biodegradable poly(amino acid) were synthesized by the reaction of poly(succinimide) with dodecylamine and amino alcohols. The introduction of the hydrophobic amine into the thermoresponsive poly(amino acid) s induced the sol-gel transition in phosphate buffer saline. The effects of the side chain structure, molecular weight, concentration of the polymer, and the additives (inorganic salts and urea) in the solution on the thermoresponsive behaviors were systematically investigated. A relationship between the lowest critical solution temperature (LCST) in the dilute solution and the viscosity reduction of the concentrated solution upon heating was observed. The present poly(amino acid) s showing a thermoresponsive sol-gel transition in aqueous solutions possess immense potential as an injectable biodegradable hydrogel system for various biomedical applications. Copyright (C) 2009 John Wiley & Sons, Ltd.
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