期刊
POLYMERS FOR ADVANCED TECHNOLOGIES
卷 22, 期 12, 页码 2643-2648出版社
WILEY-BLACKWELL
DOI: 10.1002/pat.1692
关键词
bacterial cellulose; heparin; nanohybrid; nanofibrous scaffold
资金
- National Natural Science Foundation of China [50872088, 50673076, 50539060]
- State Key Basic Research (973) Program [2007CB936100]
- National Hi-Tech Research Development (863) Program [2009AA03Z311]
Blending two polymers is a common and effective way to develop a new material with combinations of properties not possessed by individual polymers and to overcome some limitations of individual components. This study aimed at developing a novel scaffold to mimic natural extracellular matrix (ECM) and to promote blood compatibility. Heparin (Hep) and bacterial cellulose (BC), for the first time, were hybridized to prepare a novel class of nanofibrous scaffold for vascular tissue engineering by the co-synthesis process. The morphology of Hep-BC hybrid nanofiber was observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The hybrid was further characterized by Fourier transform infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The results show that hybridizing heparin brings anticoagulant sulfate groups into BC nanofiber and that Hep-BC nanofiber has a different structure in comparison to pristine BC. This work paves a new way of improving anticoagulant property of tissue engineered vessels other than coating process. Copyright (C) 2010 John Wiley & Sons, Ltd.
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