期刊
POLYMERS FOR ADVANCED TECHNOLOGIES
卷 19, 期 8, 页码 937-943出版社
WILEY
DOI: 10.1002/pat.1079
关键词
glucose-responsive polymer; poly(N-isopropylacrylamide); phenylboronic acid; rapid response; hydrogel
A new type of glucose-responsive hydrogel with rapid response to blood glucose concentration change at physiological temperature has been successfully developed. The polymeric hydrogel contains phenylboronic acid (PBA) groups as glucose sensors and thermo-responsive poly (N-isopropylacrylamide) (PNIPAM) groups as actuators. The response rate of the hydrogel to environmental glucose concentration change was significantly enhanced by introducing grafted poly(N-isopropylacrylamide-co-3-acrylamidophenylboronic acid) [poly(NIPAM-co-AAPBA)] side chains onto crosslinked poly(NIPAM-co-AAPBA) networks for the first time. The synthesized comb-type grafted poly(NIPAM-co-AAPBA) hydrogels showed satisfactory equilibrium glucose-responsive properties, and exhibited much faster response rate to glucose concentration change than normal type crosslinked poly(NIPAM-co-AAPBA) hydrogels at physiological temperature. Such glucose-responsive hydrogels with rapid response rate are highly attractive in the fields of developing glucose-responsive sensors and self-regulated drug delivery systems. Copyright (C) 2008 John Wiley & Sons, Ltd.
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