期刊
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
卷 51, 期 7, 页码 729-733出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03602559.2012.663035
关键词
2,4-Dihydroxy-5-fluoropyrimidine; Chitosan; Cytotoxicity; Microspheres; Poly(vinyl alcohol); Release behavior
资金
- National Natural Science Foundation of China [51142001]
- Hunan Provincial Natural Science Foundation of China
- Research Foundation of Education Bureau of Hunan Province, China [11B099]
- Planned Science and Technology Project of Hunan Province, China [2011TT2038]
Blend microspheres of poly(vinyl alcohol) (PVA) with chitosan (Cs) were prepared as candidates for oral delivery system. Cs/PVA microspheres containing 2,4-dihydroxy-5-fluoropyrimidine (5-FU) were obtained using glutaraldehyde (GA) as a cross-linking agent. The effects of cross-linker concentration and cross-linking time on the release of 5-FU were investigated, and the cytotoxicities of free 5-FU and the PVA/Cs microspheres loaded with 5-FU were also studied. It was observed that 5-FU release from the microspheres decreased with the increase of cross-linking concentration and cross-linking time. Cytotoxicity tests of free and entrapped 5-fluorouracil were carried out with MCF-7 breast cancer cell line. Free 5-FU produced an immediate effect, whereas entrapped 5-fluorouracil showed a prolonged cytotoxic effect.
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