期刊
BIOANALYSIS
卷 7, 期 19, 页码 2585-2595出版社
FUTURE SCI LTD
DOI: 10.4155/bio.15.173
关键词
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资金
- Career Development Fellowship from the National Health and Medical Research Council of Australia [APP1048652]
- UQ Research Scholarship (UQRS) for RHD Candidature at The University of Queensland
Background: Fosfomycin is an antibiotic of considerable interest for the treatment of infection by multidrug-resistant bacteria. Translating microsampling techniques into clinical PK studies may provide effective dosing information to improve patient outcomes and minimize the potential development of resistance. Results: Accuracy and precision results were within +/- 15%; the method was validated across the range of 5-2000 mu g/ml of fosfomycin using volumetric absorptive microsampling (VAMS) devices. Conclusion: The VAMS techniques provide acceptable validation data as assessed for lower limit of quantification, linearity, intra- and interday precision and accuracy, selectivity and matrix effects. Results from the recovery and stability studies suggest challenges remain for the analysis of fosfomycin in whole blood using VAMS.
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