期刊
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING
卷 48, 期 10, 页码 1020-1024出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/03602550903092534
关键词
Bulk modification; Cytocompatibility; Poly(L-lactic-co-glycolide); Poly(L-lactide-co-glycolide)/bioactive glass; Poly-L-lactic acid
The cytocompatibility and hydrophilicity tests were performed by culturing mouse fibroblastic cells on films of poly-L-lactic acid (PLLA), poly(L-lactic-co-glycolide) (PLGA) and poly(L-lactide-co-glycolide)/bioactive glass (PLGA/BG) or in the presence of extracts from these polymeric materials. The solvent casting method was used to prepare these films. PLLA films were most hydrophobic and PLGA/BG was least hydrophobic. Compared to the other films, PLLA showed the worst results in cytocompatibility. PLGA also showed favorable results for fibroblastic cells viability. PLGA/BG films also demonstrated improved cell compatibility due to the good biocompatibility of the bioactive glass particles. The results of this study indicate the promising biocompatibility of PLGA/BG as biomaterials in medical field.
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