Analytical applications of nanoparticles in MALDI-MS for bioanalysis

Recently, the rapid development of nanotechnology has enabled the analytical community to integrate processes with MALDI-MS for the analysis of various biomolecules. This article presents the recent progress on nanomaterials as extracting probes in single-drop microextraction, in liquid-liquid microextraction and as affinity probes for the enrichment of trace level biomolecules prior to their identification by MALDI-MS.