期刊
POLYMER TESTING
卷 32, 期 4, 页码 810-818出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.polymertesting.2013.03.017
关键词
Phthalate; Gas chromatography mass spectrometry poly(EGDMA-MATrp); Saliva; Central composite design
资金
- Research Foundation of Uludag University [KUAP(F)-2012/58]
This paper describes a method for the determination of six phthalate esters (PEs) in artificial saliva using solid phase extraction (SPE) and gas chromatography-mass spectrometry (GC-MS). A new material was developed to isolate the PEs from artificial saliva. Poly(ethylene glycol dimethacrylate-N-methacryloyl-L-tryptophan methyl ester) (poly(EGDMA-MATrp)) microspheres (average diameter = 106-300 mu m) were synthesised and characterised. Several different parameters, such as pH, adsorption time and adsorbent amount, which affect SPE, were carefully optimised by central composite design (CCD). The best analytical conditions for the simultaneous determination of the analytes from a spiked artificial saliva sample were found to be a pH of 6.8, an adsorption time of 90 min, and an adsorbent amount of 1.8 g L-1, using dichloromethane as the elution solvent. These conditions were applied to study the migration of PEs found on various children's toys into saliva. (C) 2013 Elsevier Ltd. All rights reserved.
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