期刊
POLYMER SCIENCE SERIES A
卷 53, 期 4, 页码 323-335出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0965545X11040080
关键词
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Hydrogels with the memory effect are synthesized from crosslinked copolymers of 2-hydroxyethyl methacrylate and functional monomers (acrylic acid or dimethylaminoethyl methacrylate) via the method of template synthesis with the use of the drug cephazoline as a matrix. It is shown that the hydrogels show an increased sorption activity against the target drug and a slow rate of drug release from the hydrogel (the memory effect) under certain conditions. In combination with cephazoline, these hydrogels may be regarded as a new prolonged-drug-release system for the treatment of infectious diseases.
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