期刊
POLYMER INTERNATIONAL
卷 58, 期 10, 页码 1142-1147出版社
WILEY
DOI: 10.1002/pi.2642
关键词
albumin; magnetic nanocomposites; micelles; morphology; nanoparticles
资金
- MIUR (Italian Ministry of Research and University)
BACKGROUND: Micellar systems are widely applied as reactors to encapsulate inorganic nanoparticles in polymeric materials. However, only low inorganic contents and microscale dimensions are often achieved. RESULTS: The adsorption of albumin protein on ferrite nanoparticles permits to increase the stability of inorganic dispersions in water by inhibiting particle flocculation. Subsequent glutaralclehyde addition induces protein crosslinking and ferrite entrapment. Polymer-ferrite composite nanoparticles were obtained in this way. The magnetic albumin nanoparticles (25 nm mean diameter) obtained contain about 40 wt% of ferrite and show superparamagnetic behaviour. The composite powder was successfully functionalized with a model drug and the biological activity was evaluated. CONCLUSION: Using a reverse micelle approach, ferrite-albumin composite nanoparticles with a high inorganic content were obtained. The method permits the formulation of biocompatible magnetic particles of nanoscale dimensions. The exhibited superparamagnetic behaviour permits to hypothesize an application of the powder composite as a carrier in biomedical technologies. (C) 2009 Society of Chemical Industry
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