期刊
POLYMER ENGINEERING AND SCIENCE
卷 52, 期 11, 页码 2396-2402出版社
WILEY-BLACKWELL
DOI: 10.1002/pen.23193
关键词
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资金
- Medicine and Engineering Interdisciplinary Research Foundation of Shanghai Jiao Tong University [YG2010MS60]
- Open Research Foundation of State Key Lab of Metal Matrix Composites in China [mmc-kf09-04]
- National Science Foundation of China [31000437]
A new mini-deposition system (MDS) was developed to fabricate scaffolds with interconnected pore structures and anatomical geometry for bone tissue engineering. Polycaprolactone/hydroxyapatite (PCL/HA) composites with varying hydroxyapatite (HA) content were adopted to manufacture scaffolds by using MDS with a porosity of 54.6%, a pore size of 716 mu m in the x-y plane, and 116 mu m in the z direction. The water uptake ratio and compressive modulus of PCL/HA composite scaffold increase from 8 to 39% and from 26.5 to 49.8 MPa, respectively, as the HA content increases from 0 to 40%. PCL/HA composite scaffolds have better wettability and mechanical properties than pure PCL scaffold. A PCL/HA composite scaffold for mandible bone repair was successfully fabricated with both interconnected pore structures and anatomical shape to demonstrate the versatility of MDS. POLYM. ENG. SCI., 2012. (C) 2012 Society of Plastics Engineers
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