期刊
POLYMER DEGRADATION AND STABILITY
卷 94, 期 9, 页码 1405-1410出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.polymdegradstab.2009.05.011
关键词
Oxidized sodium alginate; Hydrogel; Degradation; Swelling kinetics
资金
- Gansu Province Project of Science and Technologies [0804WCGA130]
Degradation is often a critical property of materials utilized in tissue engineering. Although alginate, a naturally derived polysaccharide, is an attractive material due to its biocompatibility and ability to form hydrogels, its slow and uncontrollable degradation can be an undesirable feature. In this study, the degradation behavior of hydrogel based on oxidized sodium alginate (OSA) crosslinked with Ca2+ was studied in phosphate buffer solution (PBS, pH = 7.4) and Tris-(hydroxymethyl) aminomethane-HCl (Tris-HCl, pH = 7.4) at 37 degrees C. The degradation behavior of OSA hydrogels with different degrees of oxidation was evaluated as a function of degradation time by monitoring the changes of molecular weight and weight loss. It was found that the degradation behavior relied heavily on the degree of oxidation and the surrounding medium. This result indicates that the degradation rates of OSA hydrogels can be controlled by changing the degree of oxidation. (C) 2009 Elsevier Ltd. All rights reserved.
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