期刊
POLYMER CHEMISTRY
卷 2, 期 6, 页码 1258-1260出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1py00071c
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资金
- Region Pays de la Loire
Well-defined poly(N-isopropylacrylamide) (PNIPAM) polymers with an oxazolone ring at the chain end have been synthesized by combining controlled radical polymerization and thiol-Michael addition click chemistry. First, PNIPAM was synthesized using reversible addition-fragmentation chain transfer (RAFT) polymerization to afford polymers of controlled molecular weight and molecular weight distribution (M-n (1H NMR) = 3200 g mol(-1); PDISEC = 1.05). The chain end was quantitatively converted to a thiol by aminolysis. Then, the functional monomer vinyl azlactone (VDM) was quantitatively clicked onto the chain end using a thiol-Michael addition reaction. The polymers were reacted with a model amine in order to demonstrate the potential of these polymers for bioconjugation.
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