4.7 Article

Orthogonal modification of polymer chain-ends via sequential nitrile oxide-alkyne and azide-alkyne Huisgen cycloadditions

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POLYMER CHEMISTRY
卷 2, 期 2, 页码 372-375

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c0py00236d

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  1. German Research Foundation (DFG) [Sfb 448]
  2. Science Foundation of Ireland [05/PICA/B838]

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The alpha- and omega-chain-ends of well-defined polystyrene chains were functionalized using consecutive Huisgen cycloadditions. Firstly, an alpha-alkyne, omega-azido heterotelechelic polystyrene precursor was synthesized in three steps: (i) atom transfer radical polymerization in the presence of (1,1,1-trimethylsilyl)-2-propynyl 2-bromo-2-isobutyrate, (ii) deprotection of the alkyne function of the initiator and (iii) nucleophilic substitution of the bromine chain-end of the polymer with sodium azide. Afterwards, the chain-ends of the polymer were modified by successive nitrile oxide-alkyne cycloaddition (NOAC) and copper-catalyzed azide-alkyne cycloaddition (CuAAC). 2 Model building blocks were tested for NOAC, while 4 building blocks were studied for CuAAC. In all cases, the orthogonal combination of NOAC and CuAAC allowed the preparation of tailored heterotelechelic polymers.

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