期刊
POLYMER BULLETIN
卷 67, 期 1, 页码 101-124出版社
SPRINGER
DOI: 10.1007/s00289-010-0407-6
关键词
Poly-NIPA; Hyaluronic acid; Thermo-sensitive; Interpenetrating polymer network; Injectable hydrogel
资金
- Decanato de Investigacion y Desarrollo (DID)
- CYTED
In this study, an hydrogel was synthesized from the monomer N-isopropylacrylamide (NIPA), generating the poly(N-isopropylacrylamide) (PNIPA) and other formulations were synthesized in the presence of 1, 2, and 3% hyaluronic acid (HA) for obtain an interpenetrating polymer network. For all the obtained hydrogels, the thermo-sensitive response was studied since the lower critical solution temperature (LCST) and was analyzed by differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), and oscillatory rheology at constant frequency as a function of temperature. The LCST transition temperature (Tt onset) was found between 34.4 and 35.5 A degrees C. By scanning electron microscopy (SEM) PNIPA-HA formulations showed a porous morphology. The applicability of the hydrogels as injectable and non-toxic materials was verified, respectively, by rheology results and by cytotoxicity studies through an in vitro test of cell hemolysis on blood agar.
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