期刊
POLYMER
卷 55, 期 3, 页码 833-839出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.polymer.2013.12.065
关键词
Polyphosphazene; Thiol-ene; Self-assembly
资金
- Fundamental Research Funds for the Central Universities [2013QNA4049]
- National Natural Science Foundation of China [21274126]
- National Twelfth Five-Year Plan for Science & Technology Support of China [2012BAI08B01]
- Open Foundation of Key Laboratory of Advanced Textile Materials and Manufacturing Technology [2012001]
Sequential thiol-ene click reaction is reported for amphiphilic glycosylated polyphosphazene. Poly [bis(allylamino)phosphazene] was used as precursor to go through UV irradiation with 2,3,4,6-tetra-O-acetyl-1-thiol-beta-D-glucopyranose (SH-GlcAc(4)) and 1-dodecanethiol in sequence. Variation of the reaction conditions, including click reaction time and the dose of photoinitiator, led to different hydrophilic/hydrophobic ratios. As a result, glycosylated polyphosphazenes were synthesized with 533%, 77.7% and 85.0% of glucose moieties. The different residual composition could give rise to different self-assembly behaviors. Micelles of amphiphilic polyphosphazenes were formed in aqueous solution and the CMC value (0.79 x 10(-3)-4.00 x 10(-3) mg/mL) as well as mean diameter (170-220 nm) varied along with the hydrophilic glucose moiety/hydrophobic dodecyl moiety ratio. (C) 2014 Elsevier Ltd. All rights reserved.
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