期刊
BMC NEPHROLOGY
卷 16, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s12882-015-0054-0
关键词
Cardiovascular event; Chronic kidney disease; Annual hospital costs; Renal replacement therapy; Resource use
资金
- Merck & Co., Inc. (Whitehouse station, NJ USA)
- Australian National Health Medical Research Council
- British Heart Foundation
- UK Medical Research Council
Background: Reliable estimates of the impacts of chronic kidney disease (CKD) stage, with and without cardiovascular disease, on hospital costs are needed to inform health policy. Methods: The Study of Heart and Renal Protection (SHARP) randomized trial prospectively collected information on kidney disease progression, serious adverse events and hospital care use in a cohort of patients with moderate-to-severe CKD. In a secondary analysis of SHARP data, the impact of participants' CKD stage, non-fatal cardiovascular events and deaths on annual hospital costs (i.e. all hospital admissions, routine dialysis treatments and recorded outpatient/day-case attendances in United Kingdom 2011 prices) were estimated using linear regression. Results: 7,246 SHARP patients (2,498 on dialysis at baseline) from Europe, North America, and Australasia contributed 28,261 years of data. CKD patients without diabetes or vascular disease incurred annual hospital care costs ranging from pound 403 (95% confidence interval: 345-462) in CKD stages 1-3B to (sic)525 (449-602) in CKD stage 5 (not on dialysis). Patients in receipt of maintenance dialysis incurred annual hospital costs of (sic)18,986 (18,620-19,352) in the year of initiation and (sic)23,326 (23,231-23,421) annually thereafter. Patients with a functioning kidney transplant incurred (sic)24,602 (24,027-25,178) in hospital care costs in the year of transplantation and (sic)1,148 (978-1,318) annually thereafter. Non-fatal major vascular events increased annual costs in the year of the event by (sic)6,133 (5,608-6,658) for patients on dialysis and by (sic)4,350 (3,819-4,880) for patients not on dialysis, and were associated with increased costs, though to a lesser extent, in subsequent years. Conclusions: Renal replacement therapy and major vascular events are the main contributors to the high hospital care costs in moderate-to-severe CKD. These estimates of hospital costs can be used to inform health policy in moderate-to-severe CKD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据