期刊
POLYHEDRON
卷 31, 期 1, 页码 294-306出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2011.09.021
关键词
Metal hydrazone complex; Crystal structure; Protein interaction; Antioxidant; Antimicrobial
资金
- Department of Science and Technology (DST)
Bivalent transition metal hydrazone complexes of the composition [Ni(L-1)(2)] (1), [Co(L-1)(2)] (2), [Ni(L-2)(2)] (3) and [Co(L-2)(2)] (4) have been synthesised from the reactions of [MCl2(PPh3)(2)] (where M = Ni or Co) with hydrazones derived from 2-acetyl pyridine and carboxylic acid hydrazides of benzhydrazide (HL1) or thiophene-2-carboxylic acid hydrazide (HL2), respectively. Structure of the ligands HL1 and HL2 and their corresponding complexes with Ni(II) and Co(II) ions were proposed based on the elemental analysis, infrared and H-1 NMR spectral methods. Single crystal X-ray diffraction study of complex 1 revealed a distorted octahedral geometry around the metal ion provided by two units of the ligand. To explore the potential medicinal value of the new complexes, binding interaction of all the complexes with bovine serum albumin (BSA) was studied at normal physiological conditions using fluorescence and UV-Vis spectral techniques. The number of binding sites (n) and binding constant (K-a) were calculated according to the double logarithm regression equation. The results of synchronous fluorescence spectrum showed that binding of metal hydrazones with BSA induced conformational changes in BSA. The in vitro antioxidant and antimicrobial potentials of the new chelates were also carried out. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据