期刊
POLYHEDRON
卷 30, 期 13, 页码 2186-2194出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2011.05.048
关键词
Schiff base; Cu-Zn complex; Crystal structure; Urease inhibition
资金
- National Science Foundation of China [20901036]
A series of hetero-dinuclear Cu-II-Zn-II complexes, [CuZnCl2L1] (1), [CuZnCl2L2] (2), [CuZnBr2L3] (3), [CuZnBr2L4(DMF)] (4), [CuZnCl2L4] (5), [CuZnCl2L5] (6), [CuZnCl2L3] (7) and [CuZnBr2L1] (8), where L-3, L-4 and L-5 are the deprotonated forms of N,N'-bis(3-ethoxysalicylidene)-1,3-propanediamine (H2L1), N,N'-bis(2-hydroxynaphthylmethylidene)-1,3-propanediamine (H2L2), N,N'-bis(3-methoxysalicylidene)-1,3-propanediamine (H2L3), N,N'-bis(salicylidene)-1,3-propanediamine (H2L4) and N,N'-bis(salicylidene)1,4-butanediamine (H2L5), respectively, have been synthesized and characterized by physico-chemical methods and single-crystal X-ray diffraction. The complexes were tested for their urease inhibitory activity. Complexes 1 and 8 show effective urease inhibitory activity with IC50 values of 2.2 and 10.7 mu M. The molecular docking study of the complexes with the Helicobacter pylori urease was performed. (C) 2011 Elsevier Ltd. All rights reserved.
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