期刊
POLISH JOURNAL OF PATHOLOGY
卷 65, 期 2, 页码 125-129出版社
VESALIUS UNIV MEDICAL PUBL
DOI: 10.5114/PJP.2014.43962
关键词
lipopolysaccharide (LPS); mesenteric lymph node; percentage of CD4(+)CD25(+)Foxp3(+) Treg; Th1/Th2 ratio
类别
资金
- National Key Basic Research Program (973 Program) of the Ministry of Science and Technology of the People's Republic of China
Our aims were to study the influence of the mesenteric lymph nodes (MLN) of rats on systemic lipopolysaccharide and to identify the factor that affects the intestinal endotoxin translocation. Ninety-six male Wistar rats were randomly divided into a sham-operation group (S group) and a cecal ligation and perforation group (CLP group). Twenty-four hours after modeling, we tested the Th1/Th2 ratio and percentage of CD4(+)CD25(+)Foxp3(+) Treg in the MLN. At the same time, the lipopolysaccharide (LPS) in the abdominal aortic blood was detected. In the CLP group, the Th1/Th2 ratio was obviously lower than in the S group. Otherwise, the percentage of CD4(+)CD25(+)Foxp3(+) Treg of the CLP group was significantly higher than the S group. In the abdominal aortic blood, the LPS level of the CLP group was also higher than in the S group. Through correlation analysis, we found that the level of LPS was positively correlated with the percentage of CD4(+)CD25(+)Foxp3(+) Treg, and negatively correlated with the Th1/Th2 ratio. This model reveals that the immune suppression of the MLN might affect the level of LPS in the abdominal aortic blood, which might play a certain role in affecting the endotoxin translocation.
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