期刊
ENVIRONMENTAL MICROBIOLOGY REPORTS
卷 7, 期 5, 页码 698-708出版社
WILEY
DOI: 10.1111/1758-2229.12289
关键词
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资金
- Agence Francaise de Securite Sanitaire de l'Environnement et du Travail [ES-05-01, EST-09-21]
- Agence Nationale pour la Recherche [05-9-114]
- Institut National de la Sante et de la Recherche Medicale (INSERM) [C06-18, C10-19]
- Centre National de Reference 'Resistance bacterienne dans les flores commensales'
- French government's investissement d'Avenir program, Laboratoire d'Excellence 'Integrative Biology of Emerging Infectious Diseases' [ANR-10-LABX-62-IBEID]
- EU-FP7 project EVOTAR
- EU-FP7 project R-Gnosis
In this study, we quantitatively evaluated the spread of resistance to -lactams and of integrons in small rodents and marsupials living at various distances from a point of antibiotic's use. Rectal swabs from 114 animals were collected in Trois-Sauts, an isolated village in French Guiana, and along a 3km transect heading through the non-anthropized primary forest. Prevalence of ticarcillin-resistant enterobacteria was 36% (41/114). Klebsiella spp., naturally resistant to ticarcillin, were found in 31.1% (23/73) of animals from the village and in an equal ratio of 31.7% (13/41) of animals trapped along the transect. By contrast Escherichia coli with acquired resistance to ticarcillin were found in 13.7% (10/73) of animals from the village and in only 2.4% (1/41) of those from the transect (600m from the village). There was a huge diversity of E. coli and Klebsiella pneumoniae strains with very unique and infrequent sequence types. The overall prevalence of class 1 integrons carriage was 19.3% (22/114) homogenously distributed between animals from the village and the transect, which suggests a co-selection by a non-antibiotic environmental factor. Our results indicate that the anthropogenic acquired antibiotic resistance did not disseminate in the wild far from the point of selective pressure.
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