期刊
PLOS ONE
卷 12, 期 1, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0169886
关键词
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资金
- Fonds Wetenschappelijk Onderzoek (FWO), Belgium [3M090531]
- National Institutes of Environmental Health Sciences, US [R01ES021733]
Aims This study aimed to investigate the effects of nanomaterial (NM) exposure on DNA methylation. Methods and Results Intra-tracheal administration of NM: gold nanoparticles (AuNPs) of 5-, 60-and 250-nm diameter; single-walled carbon nanotubes (SWCNTs) and multi-walled carbon nanotubes (MWCNTs) at high dose of 2.5 mg/kg and low dose of 0.25 mg/kg for 48 h to BALB/c mice. Study showed deregulations in immune pathways in NM-induced toxicity in vivo. NM administration had the following DNA methylation effects: AuNP 60 nm induced CpG hypermethylation in Atm, Cdk and Gsr genes and hypomethylation in Gpx; Gsr and Trp53 showed changes in methylation between low-and high-dose AuNP, 60 and 250 nm respectively, and AuNP had size effects on methylation for Trp53. Conclusion Epigenetics may be implicated in NM-induced disease pathways.
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