期刊
CHEMICAL SCIENCE
卷 6, 期 12, 页码 6731-6738出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc03251b
关键词
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资金
- National Natural Science Foundation of China [21302090, 21572097]
- Thousand Young Talents Program, South University of Science and Technology of China [FRG-SUSTC1501A-56]
- Shenzhen special funds for development of biomedicine, internet, new energy, and new material industries [JCYJ20150331101823694]
There are a large number of synthetic macrocyclic receptors in the literature. No particular one is suitable for all guests or purposes. For a broader guest binding scope or multiple purposes, a macrocycle with multiple interconvertible cavities will be advantageous. Here, we report a naphthalene-based macrocyclic receptor with an adaptable cavity, namely oxatub[4]arene. It has four representative conformations resulting from the flipping of naphthalene rings, each with a deep and well-defined cavity. Different guests select one host conformer or a combination of conformers. All the four conformers have been detected and characterized based on 2D NMR spectra and X-ray single crystal structures. Thermodynamically, these conformers constitute a reservoir, that responds to the structural changes of guests, and thus maximizes the association free energies. This smart macrocycle may provide a new platform for the construction of molecular machines and devices or stimuli-responsive materials.
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