期刊
CHEMICAL SCIENCE
卷 6, 期 2, 页码 1094-1100出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc03101f
关键词
-
资金
- German Research Foundation [ME 1805/4-1]
A rhodium-based asymmetric catalyst is introduced which derives its optical activity from octahedral centrochirality. Besides providing the exclusive source of chirality, the rhodium center serves as a Lewis acid by activating 2-acyl imidazoles through two point binding and enabling a very effective asymmetric induction mediated by the propeller-like C-2-symmetrical ligand sphere. Applications to asymmetric Michael additions (electrophile activation) as well as asymmetric alpha-aminations (nucleophile activation) are disclosed, for which the rhodium catalyst is found to be overall superior to its iridium congener. Due to its straightforward proline-mediated synthesis, high catalytic activity (catalyst loadings down to 0.1 mol%), and tolerance towards moisture and air, this novel class of chiral-at-rhodium catalysts will likely to become of widespread use as chiral Lewis acid catalysts for a large variety of asymmetric transformations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据