期刊
CHEMICAL SCIENCE
卷 6, 期 5, 页码 2806-2811出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc00360a
关键词
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资金
- Mid-Career Researcher Program of National Research Foundation of Korea (NRF) - Korean government (MSIP) [2013R1A2A1A01015998]
- BK21 Plus Program
As a new model of chemical assay-guided natural product isolation, an effective chemodosimetric assay system was devised. Our chemical assay system features a fluorogenic chemodosimeter immobilized on a solid support, which offers advantages in identifying the desired compounds in complex natural product mixtures. To isolate only compounds with the target functional groups, the click chemistry concept was adopted. The model system presented here was developed for natural products with a terminal alkyne. Using our newly designed alkyne sensing beads with the aforementioned features, we have readily identified, quantified, and isolated compounds with a terminal alkyne group from plant extracts.
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