期刊
CHEMICAL SCIENCE
卷 6, 期 2, 页码 1258-1264出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc03075c
关键词
-
资金
- EPSRC [EP/H024107/1, EP/I033459/1, EP/J015156/1, EP/L0236521/1]
- University of Glasgow
- WestCHEM
- Royal Society/Wolfson Foundation
- EPSRC [EP/E062814/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I033459/1, EP/E062814/1, EP/J015156/1] Funding Source: researchfish
A configurable platform for synthetic chemistry incorporating an in-line benchtop NMR that is capable of monitoring and controlling organic reactions in real-time is presented. The platform is controlled via a modular LabView software control system for the hardware, NMR, data analysis and feedback optimization. Using this platform we report the real-time advanced structural characterization of reaction mixtures, including F-19, C-13, DEPT, 2D NMR spectroscopy (COSY, HSQC and F-19-COSY) for the first time. Finally, the potential of this technique is demonstrated through the optimization of a catalytic organic reaction in real-time, showing its applicability to self-optimizing systems using criteria such as stereoselectivity, multi-nuclear measurements or 2D correlations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据