期刊
CHEMICAL SCIENCE
卷 6, 期 3, 页码 2002-2009出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc03641g
关键词
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资金
- 973 program [2013CB93390]
- NSF China [21272196, 21305116, 91429301, 31420103910, 31330047, 31221065]
- 111 Project [B12001]
- PCSIRT
- Fundamental Research Funds for the Central Universities [2011121020]
- State Key Laboratory of Chemo/biosensing and Chemometrics [2012002]
- National Scientific and Technological Major Project [2013ZX10002-002]
- Hi-Tech Research and Development Program of China (863 program) [2012AA02A201]
- Science and Technology Foundation of Xiamen [3502Z20130027]
- National Science Foundation of China for Fostering Talents in Basic Research [J1310027]
- Open Research Fund of State Key Laboratory of Cellular Stress Biology, Xiamen University
Activatable molecular systems enabling precise tumor localization are valuable for complete tumor resection. Herein, we report sialic acid-capped polymeric nanovesicles encapsulating the near infrared profluorophore (pNIR@P@SA) for lysosome activation based dual modality tumor imaging. The probe features surface-anchored sialic acid for tumor targeting and a core of near infrared profluorophore (pNIR) which undergoes lysosomal acidity triggered isomerization to give optical and optoacoustic signals upon cell internalization. Imaging studies reveal high-efficiency uptake and signal activation of pNIR@P@SA in subcutaneous tumors and millimeter-sized liver tumor foci in mice. The high tumor-to-healthy organ signal contrasts and discernment of tiny liver tumors from normal liver tissues validate the potential of pNIR@P@SA for high performance optical and optoacoustic imaging guided tumor resection.
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