期刊
CHEMICAL SCIENCE
卷 6, 期 1, 页码 770-776出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc01525h
关键词
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资金
- European Research Council (ERC) [280010]
- Ramon Areces Foundation
- Ubbo Emmius fellowship
- Ministry of Education Culture and Science [024.001.035]
- European Research Council (ERC) [280010] Funding Source: European Research Council (ERC)
Artificial metalloenzymes have emerged as an attractive new approach to enantioselective catalysis. Herein, we introduce a novel strategy for preparation of artificial metalloenzymes utilizing amber stop codon suppression methodology for the in vivo incorporation of metal-binding unnatural amino acids. The resulting artificial metalloenzymes were applied in catalytic asymmetric Friedel-Crafts alkylation reactions and up to 83% ee for the product was achieved.
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