期刊
CHEMICAL SCIENCE
卷 6, 期 1, 页码 486-491出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc02638a
关键词
-
资金
- Chinese Ministry of Education [NCET-11-0688, IRT1169, RFDP-20110143120006, 2012-YB-04, NFSC-51101115, NFSC-51472190]
Self-repair is nature's way of protecting living organisms. However, most single cells are inherently less capable of self-repairing, which greatly limits their wide applications. Here, we present a self-assembly approach to create a nanoshell around the cell surface using nanoporous biohybrid aggregates. The biohybrid shells present self-repairing behaviour, resulting in high activity and extended viability of the encapsulated cells (eukaryotic and prokaryotic cells) in harsh micro-environments, such as under UV radiation, natural toxin invasion, high-light radiation and abrupt pH-value changes. Furthermore, an interaction mechanism is proposed and studied, which is successful to guide design and synthesis of self-repairing biohybrid shells using different bioactive molecules.
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