期刊
PLOS ONE
卷 11, 期 12, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0167758
关键词
-
资金
- National Human Genome Research Institute (NHGRI)
- National Institutes of Health [U01HG004803, U01HG004802, U01HG004790, U01HG004801]
- NHGRI PAGE II program [U01HG004802]
- National Cancer Institute [R37CA54281, R01 CA63, P01CA33619, U01CA136792, U01CA98758]
- NHGRI PAGE program [U01HG004803, U01HG004790]
- National Heart, Lung, and Blood Institute (NHLBI)
- US Department of Health and Human Services [N01WH22110, 24152, 32100-2, 32105-6, 32108-9, 32111-13, 32115, 32118-32119, 32122, 42107-26, 42129-32, 44221]
- NHLBI [N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021, N01-HC-55022, N01-HC-95095, N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, N01-HC-45134, N01-HC-05187, N01-HC-45205, N01-HC-85079]
- National Institute of Neurological Disorders and Stroke
- National Center for Research Resources [M01-RR00425]
- National Institute of Diabetes and Digestive and Kidney Diseases [DK063491]
- National Center on Minority Health and Health Disparities
- National Institute on Deafness and Other Communication Disorders
- National Institute of Dental and Craniofacial Research
- National Institute of Diabetes and Digestive and Kidney Diseases
- Office of Dietary Supplements
- Andrea and Charles Bronfman Philantropies
- [N01-HC-85086]
- [N01-HC-35129]
- [N01-HC-15103]
- [N01 HC-55222]
- [N01-HC-75150]
- [N01-HC-45133]
- [U01HL080295]
- [R01 HL087652]
- [N01-HC65233]
- [N01-HC65234]
- [N01-HC65235]
- [N01-HC65236]
- [N01-HC65237]
- [U01 HL65520]
- [U01 HL41642]
- [U01 HL41652]
- [U01 HL41654]
- [U01 HL65521]
Investigating genetic architecture of complex traits in ancestrally diverse populations is imperative to understand the etiology of disease. However, the current paucity of genetic research in people of African and Latin American ancestry, Hispanic and indigenous peoples in the United States is likely to exacerbate existing health disparities for many common diseases. The Population Architecture using Genomics and Epidemiology, Phase II (PAGE II), Study was initiated in 2013 by the National Human Genome Research Institute to expand our understanding of complex trait loci in ethnically diverse and well characterized study populations. To meet this goal, the Multi-Ethnic Genotyping Array (MEGA) was designed to substantially improve fine-mapping and functional discovery by increasing variant coverage across multiple ethnicities at known loci for metabolic, cardiovascular, renal, inflammatory, anthropometric, and a variety of lifestyle traits. Studying the frequency distribution of clinically relevant mutations, putative risk alleles, and known functional variants across multiple populations will provide important insight into the genetic architecture of complex diseases and facilitate the discovery of novel, sometimes population-specific, disease associations. DNA samples from 51,650 self-identified African ancestry (17,328), Hispanic/Latino (22,379), Asian/Pacific Islander (8,640), and American Indian (653) and an additional 2,650 participants of either South Asian or European ancestry, and other reference panels have been genotyped on MEGA by PAGE II. MEGA was designed as a new resource for studying ancestrally diverse populations. Here, we describe the methodology for selecting trait-specific content for use in multi-ethnic populations and how enriching MEGA for this content may contribute to deeper biological understanding of the genetic etiology of complex disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据