4.8 Article

Controlling the activity of quorum sensing autoinducers with light

期刊

CHEMICAL SCIENCE
卷 6, 期 6, 页码 3593-3598

出版社

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5sc00215j

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  1. Netherlands Organization for Scientific Research (NWO-CW)
  2. Royal Netherlands Academy of Arts and Sciences (KNAW)
  3. European Research Council (ERC) [227897]
  4. Ministry of Education, Culture and Science [024.001.035]

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Bacteria use a communication system, called quorum sensing (QS), to organize into communities and synchronize gene expression to promote virulence and secure survival. Here we report on a proof-of-principle for externally interfering with this bacterial communication system, using light. By employing photoswitchable small molecules, we were able to photocontrol the QS-related bioluminescence in an Escherichia coli reporter strain, and the expression of target QS genes and pyocyanin production in Pseudomonas aeruginosa.

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