Loss of Renal Tubular PGC-1α Exacerbates Diet-Induced Renal Steatosis and Age-Related Urinary Sodium Excretion in Mice

The kidney has a high energy demand and is dependent on oxidative metabolism for ATP production. Accordingly, the kidney is rich in mitochondria, and mitochondrial dysfunction is a common denominator for several renal diseases. While the mitochondrial master regulator peroxisome proliferator-activated receptor. coactivator 1 alpha (PGC-1 alpha) is highly expressed in kidney, its role in renal physiology is so far unclear. Here we show that PGC-1 alpha is a transcriptional regulator of mitochondrial metabolic pathways in the kidney. Moreover, we demonstrate that mice with an inducible nephron-specific inactivation of PGC-1 alpha in the kidney display elevated urinary sodium excretion, exacerbated renal steatosis during metabolic stress but normal blood pressure regulation. Overall, PGC-1 alpha seems largely dispensable for basal renal physiology. However, the role of PGC-1 alpha in renal mitochondrial biogenesis indicates that activation of PGC-1 alpha in the context of renal disorders could be a valid therapeutic strategy to ameliorate renal mitochondrial dysfunction.