期刊
CHEMICAL SCIENCE
卷 6, 期 2, 页码 930-934出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4sc02696a
关键词
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资金
- National Natural Science Foundation of China [21274058]
- National Basic Research Program of China [2013CB922101, 2011CB935801]
Current multiplexed analysis methods suffer from either slow reaction kinetics (planar arrays) or complicated encoding/decoding procedures (suspension arrays). We report herein a multiplexed DNA detection strategy that addresses these issues, based on positional encoding/decoding with self-assembled DNA nanostructures. The strategy enables the acquisition of high-resolution, consistent, and quantitative assay results in a single round of a transmission electron microscopy imaging operation. Applications in polymerase chain reaction-free settings and assays of other structurally distinct targets can be anticipated through the implementation of the strategy with miniaturized femtoliter/attoliter dispensing technology and readily accessible DNA conjugate structures.
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