期刊
PLOS ONE
卷 10, 期 7, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0132004
关键词
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资金
- Wellcome Trust [091857/Z.10/Z]
- British Heart Foundation [PG/12/33/29546]
- British Heart Foundation [PG/12/33/29546, RG/11/1/28684] Funding Source: researchfish
- Cancer Research UK [18245] Funding Source: researchfish
- Wellcome Trust [091857/Z/10/Z] Funding Source: Wellcome Trust
As part of the cellular adaptation to limiting oxygen availability in animals, the expression of a large set of genes is activated by the upregulation of the hypoxia-inducible transcription factors (HIFs). Therapeutic activation of the natural human hypoxic response can be achieved by the inhibition of the hypoxia sensors for the HIF system, i.e. the HIF prolyl-hydroxylases (PHDs). Here, we report studies on tricyclic triazole-containing compounds as potent and selective PHD inhibitors which compete with the 2-oxoglutarate co-substrate. One compound (IOX4) induces HIF alpha in cells and in wildtype mice with marked induction in the brain tissue, revealing that it is useful for studies aimed at validating the upregulation of HIF for treatment of cerebral diseases including stroke.
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