期刊
PLOS ONE
卷 10, 期 4, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0124923
关键词
-
资金
- Health and Labour Sciences Research Grants on Intractable Diseases from the Ministry of Health, Labour and Welfare, Japan [H24-Nanchitou (Nan)-Ippan-055, H23-Nanchi-Ippan-017]
- Ministry of Education, Culture, Sports, Science and Technology, Japan [25293204, 25670423, 25117012]
- Bayer Schering Pharma
- Biogen Idec
- Novartis Pharma
- Mitsubishi Tanabe Pharma
- Ministry of Health, Labour and Welfare of Japan
- Japan Science and Technology Agency
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Kaibara Morikazu Medical Science Promotion Foundation, Japan
- Ministry of Health, Labour and Welfare, Japan
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Pfizer Japan
- Japan Blood Products Organization
- Grants-in-Aid for Scientific Research [25670423] Funding Source: KAKEN
Background Fingolimod efficiently reduces multiple sclerosis (MS) relapse by inhibiting lymphocyte egress from lymph nodes through down-modulation of sphingosine 1-phosphate (S1P) receptors. We aimed to clarify the alterations in peripheral blood T cell subsets associated with MS relapse on fingolimod. Methods/Principal Findings Blood samples successively collected from 23 relapsing-remitting MS patients before and during fingolimod therapy (0.5 mg/day) for 12 months and 18 healthy controls (HCs) were analysed for T cell subsets by flow cytometry. In MS patients, the percentages of central memory T (CCR7(+)CD45RO(+)) cells (TCM) and naive T (CCR7(+)CD45RO(-)) cells decreased significantly, while those of effector memory T (CCR7-CD45RA-) and suppressor precursor T (CD28-) cells increased in both CD4(+)T and CD8(+)T cells from 2 weeks to 12 months during fingolimod therapy. The percentages of regulatory T (CD4(+)CD25(high)CD127(low)) cells in CD4(+)T cells and CCR7(-)CD45RA(+)T cells in CD8(+)T cells also increased significantly. Eight relapsed patients demonstrated greater percentages of CD4(+)TCM than 15 non-relapsed patients at 3 and 6 months (p=0.0051 and p=0.0088, respectively). The IL17-, IL9-, and IL4-producing CD4(+)T cell percentages were significantly higher at pre-treatment in MS patients compared with HCs (p<0.01 for all), while the IL17-producing CD4(+)T cell percentages tended to show a transient increase at 2 weeks of fingolimod therapy (p(corr)=0.0834). Conclusions The CD4(+)TCM percentages at 2 weeks to 12 months during fingolimod therapy are related to relapse.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据