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A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein Uptake
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A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
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PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide
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Plasma PCSK9 preferentially reduces liver LDL receptors in mice
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TRAFFIC (2007)
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
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Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
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